VETERINARY AND COMPARATIVE

PHARMACOKINETIC WORKSHOP

2011 COMPARATIVE PHARMACOKINETIC WORKSHOP

October 3-4, 2011
Location: Raleigh, NC

The focus of this two day workshop, now offered nine times since 2003 in Raleigh or at CVM-FDA, is to provide attendees a comprehensive review of pharmacokinetic principles applied to veterinary and comparative medicine. A goal of the course will be to integrate basic concepts into practical applications. Topic to be covered include fundamental concepts of modeling, pharmacokinetic parameters, compartmental versus non-compartmental approaches, study design, bioequivalence, estimating withdrawal times, estimating dosage regimens, modern software, practical statistics involved in curve fitting, therapeutic drug monitoring, population pharmacokinetics, interspecies extrapolation and effect of disease or interactions on pharmacokinetics in animals.

Instructors for this course are Drs. Mark Papich and Jim Riviere. All attendees will receive a copy of: Riviere: Comparative Pharmacokinetic: Principles, Techniques and Applications. 2^nd Edition, Wiley-Blackwell, 2010.

The venue for this course is the Blue Ridge Ramada Inn, 1520 Blue Ridge Road, Raleigh, NC . A block of rooms is being held and should be reserved as early as possible (Phone: 919-832-4100, mention Block Code: CGPHAR; $75/night plus tax). Room includes free internet and breakfast buffet. Course registration is $1,500 / attendee and includes lunch, refreshment breaks, textbook and notes.

A check (no credit cards) made payable to Riviere Consulting should be mailed to:

Pharmacokinetic Workshop
Riviere Consulting
P.O. Box 30474
Raleigh, NC 27622

EMAIL: Riviere@Ureach.com

Cutoff deadline for paid registration is September 16th, 2011. Please provide full contact information with payment.

TENTATIVE PROGRAM SCHEDULE: October 3-4, 2011

Monday, October 3rd

8:30 -9:00 Arrival and pick-up workshop materials.

9:00-9:45 Introduction to pharmacokinetic modeling (JR)

9:45-10:30 Pharmacokinetic principles: Part I (MP)

BREAK Coffee break

10:45-11:15 Pharmacokinetic principles: Part II (MP)

11:15-12:00 Absorption of drugs (JR)

LUNCH

1:00-1:45 Absorption of drugs: clinical applications (MP)

1:45-2:30 Absorption of drugs from non-oral sites (MP)

BREAK Coffee break

2:45-3:30 Distribution and elimination (JR)

3:30-4:00 Determination of dosage regimens (MP)

Tuesday, October 4th

8:30 -9:00 Arrival and set-up.

9:00-10:00 Compartmental modeling (JR)

10:00-10:30 Statistical issues in pharmacokinetics (JR)

BREAK Coffee break

10:45-11:30 Drug penetration: factors that determine tissue penetration (MP)

11:30-12:00 Drug penetration to specific sites (MP)

LUNCH

1:00-1:45 Other modeling approaches: Non-compartmental, population-PK, PBPK (JR)

1:45-2:30 PK-PD concepts (MP)

BREAK.

2:45-3:30 Allometry and pharmacokinetics of tissue residues (JR)

3:30-4:00 Drug interactions that affect pharmacokinetics (MP)

JR = Dr. Jim Riviere MP = Dr. Mark Papich